Major Lazer, el proyecto de música electrónica liderado por Diplo, consigue el número uno con el tema Light it up junto con Nyla y Fuse ODG. Es la segunda vez que el grupo estadounidense llega a liderar la lista, tras conseguirlo en mayo de 2015 con Lean on.
| 1 | Major Lazer ft Nyla & Fuse ODG | Light it up (Remix) |
| 2 | Alan Walker | Faded |
| 3 | Lukas Graham | 7 years |
| 4 | 99 Souls feat Destiny's Child | The girl is mine |
| 5 | Twenty One Pilots | Stressed out |
| 6 | Jonas Blue feat Dakota | Fast car |
| 7 | Justin Bieber | Love yourself |
| 8 | Coldplay | Hymn for the weekend |
| 9 | Miss Caffeina | Mira cómo vuelo |
| 10 | Adele | When we were young |
| 11 | Rihanna feat Drake | Work |
| 12 | Ellie Goulding | Something in the way you move |
| 13 | Shakira | Try everything |
| 14 | Jason Derulo | Get ugly |
| 15 | Nicky Jam | Hasta el amanecer |
| 16 | Josef Salvat | Open season |
| 17 | Paulina Rubio | Si te vas |
| 18 | Sia feat Sean Paul | Cheap thrills |
| 19 | Zayn | Pillowtalk |
| 20 | Matt Simons | Catch & release (Deepend remix) |
| 21 | Taylor Swift | Out of the woods |
| 22 | Omi feat AronChupa | Drop in the ocean |
| 23 | The 1975 | Sound |
| 24 | Flo Rida | My house |
| 25 | Auryn feat Anastacia | Who's loving you? |
| 26 | Charlie Puth | One call away |
| 27 | Supersubmarina | Algo que sirva como luz |
| 28 | Alessia Cara | Here |
| 29 | Selena Gomez | Hands to myself |
| 30 | Mike Posner | In Ibiza (SeeB remix) |
| 31 | Dua Lipa | Be the one |
| 32 | Pablo Alborán | Palmeras en la nieve |
| 33 | Tiësto & O. Heldens ft N. La Rose | The right song |
| 34 | Marco Mengoni | Invencible |
| 35 | Fangoria | Fiesta en el infierno |
| 36 | Julian Perretta | Miracle |
| 37 | Kostrok feat Bearoid | Made of wood |
| 38 | The Vamps | Rest your love |
| 39 | The Chainsmokers | Roses |
| 40 | Feder | Blind |
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