Luis Fonsi lidera esta semana la lista, con su nuevo single 'Despacito', junto con Daddy Yankee. Es la segunda vez que el puertorriqueño llega al número uno, tras haberlo conseguido en 2008 con 'No me doy por vencido'. Además entran cuatro nuevas canciones.
| Nº | AN | TÍTULO / ARTISTA | SE | MX |
| 1 | 2 | Despacito / Luis Fonsi ft Daddy Yankee | 3 | 1 |
| 2 | 1 | Shape of you / Ed Sheeran | 2 | 1 |
| 3 | 3 | I feel it coming / The Weeknd feat Daft Punk | 10 | 2 |
| 4 | 5 | Alone / Alan Walker | 7 | 4 |
| 5 | 6 | I don't wanna live forever / Zayn & Taylor Swift | 8 | 1 |
| 6 | 4 | Just hold on / Steve Aoki ft Louis Tomlinson | 7 | 4 |
| 7 | 8 | Paris / The Chainsmokers | 3 | 7 |
| 8 | 11 | Move your body (single mix) / Sia | 7 | 8 |
| 9 | 7 | Rockabye / Clean Bandit ft Sean Paul | 14 | 1 |
| 10 | 9 | September song / JP Cooper | 11 | 9 |
| 11 | 15 | Complicidad / Vanesa Martín ft. Manuel Medrano | 5 | 11 |
| 12 | 12 | Ando buscando / Carlos Baute ft Piso 21 | 6 | 12 |
| 13 | 10 | Shed a light / Robin Schulz & David Guetta | 10 | 2 |
| 14 | 13 | La lluvia en los zapatos / Leiva | 10 | 9 |
| 15 | 16 | Diciembre / La oreja de Van Gogh | 7 | 15 |
| 16 | N | Run up / Major Lazer ft Nicki Minaj | 1 | 16 |
| 17 | 20 | I got u / Bebe Rexha | 6 | 17 |
| 18 | 24 | Espectacular / Fangoria | 3 | 18 |
| 19 | N | Scared to be lonely / Martin Garrix & Dua Lipa | 1 | 19 |
| 20 | 21 | Good girls / Crystal Fighters | 5 | 20 |
| 21 | 27 | Should've been me / Naughty Boy ft Kyla | 6 | 21 |
| 22 | 26 | Inside the lines / Mike Perry ft Casso | 8 | 22 |
| 23 | 25 | Tuesday / Burak Yeter ft D. Sandoval | 2 | 23 |
| 24 | 18 | Human / Rag'n'Bone Man | 12 | 1 |
| 25 | N | Siempre brilla el Sol / Lori Meyers | 1 | 25 |
| 26 | 19 | All night / Beyoncé | 5 | 19 |
| 27 | 31 | Now & later / Sage the Gemini | 4 | 27 |
| 28 | 30 | Love like we used to / Captain Cuts ft Nateur | 2 | 28 |
| 29 | 32 | What if / Tokio Hotel | 3 | 29 |
| 30 | 17 | Cenizas / Malú | 6 | 12 |
| 31 | 14 | No lie / Sean Paul ft Dua Lipa | 11 | 7 |
| 32 | 22 | Water under the bridge / Adele | 9 | 14 |
| 33 | 35 | Pólvora mojada / Rayden | 2 | 33 |
| 34 | N | On my way / Tiësto | 1 | 34 |
| 35 | 33 | Places / Martin Solveig | 4 | 29 |
| 36 | 23 | Miss you / Gabrielle Aplin | 8 | 17 |
| 37 | 38 | Hear me now / Alok ft Bruno Martini & Zeeba | 2 | 37 |
| 38 | 36 | Only one / Sigala & Digital Farm Animals | 5 | 33 |
| 39 | 28 | I would like / Zara Larsson | 7 | 16 |
| 40 | 37 | You're not there / Lukas Graham | 4 | 30 |
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